Corneal Antigen-Presenting Cells: Diversity, Plasticity, and Disguise The Cogan Lecture

Corneal antigen-presenting cells: diversity, plasticity, and disguise: the Cogan lecture.

The study of antigen-presenting cells (APCs) is important for all immune-mediated disorders because these cells are not only the “sentinels” of the immune system for detection of foreign antigens, but they also play a critical role in tolerance induction to both selfand foreign antigens. In addition to their role in immune surveillance and induction of antigenspecific immune reactivity and tole...

PITs and FOXes in ocular genetics: the Cogan lecture.

The overall goal of the research in my laboratory is to gain better understanding of the molecular biology of the anterior segment and, in particular, to identify genes that regulate the development and function of this tissue. We have concentrated on discovering and characterizing the genes that, when mutated, cause anterior segment dysgenesis (ASD). ASD encompasses a spectrum of inherited aut...

The Immunomodulatory Effect of Cyclophosphamide on Regulation of T-Cell Subsets and Antigen Presenting Cells.

Eye cancer: unique insights into oncogenesis: the Cogan Lecture.

The major objective of this lecture is to illustrate how eye cancer research has dramatically affected not only patients with these ocular tumors, but also our fundamental understanding of cancer biology and many other aspects of biomedical research. Retinoblastoma and uveal melanoma, the two most common eye cancers in children and adults, respectively, are very different clinically and biologi...

The double-edged ocular immune response: the Cogan lecture.

The immune system has evolved to protect the body against infectious microbes and toxic insults. To achieve this mission, the immune system contains a plethora of well-choreographed defense mechanisms. Cells of the immune system, such as specific killer T cells, natural killer cells, polymorphonuclear leukocytes, and macrophages, directly attack pathogens. Cells involved in humoral and cellular...